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. 2021 Mar 16;17(3):239–252. doi: 10.1080/15592294.2021.1896984

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Figure 2. — Methylated filler DNA is needed to compensate for low-input methylation enrichment.

(a,b) Total normalized CpG islands coverage and CpG islands/shores/shelves coverage across different methylation states of filler DNA. (N = 4 for the first condition, N = 3 for other conditions. Mean with SEM.) (c) Coverage by CpG density plots across different methylation states of filler DNA. (d) The CpG density at peak (left y-axis) and noise (right y-axis) at different methylation states of filler DNA.