Table 2.
First dose N (%) N = 1086 | Second dose N(%) N = 299 | P value | |
---|---|---|---|
Local symptoms Injection site pain Swelling and redness of injection site |
851 (78.4) 177 (16.3) |
200 (66.8) 45 (15.0) |
0.004 0.216 |
Bone and muscle pain | 408 (37.6) | 85 (28.4) | <0.001 |
Flu like symptoms Fever Headache Chills Sore throat Fatigue Cough Runny nose Loss of taste Loss of smell |
300 (27.6) 359 (33.1) 351 (32.3) 90 (8.3) 563 (51.8) 91 (8.4) 76 (7.0) 14 (1.3) 16 (1.5) |
57 (19.1) 59 (19.7) 69 (23.1) 18 (6.0) 121 (40.4) 10 (3.3) 14 (4.6) 2 (0.7) 3 (1.0) |
<0.001 <0.001 <0.001 0.031 <0.001 0.048 0.115 0.264 0.428 |
GI side effect Nausea Diarrhea Vomiting Loss of appetite Abdominal pain Constipation |
164 (15.1) 70 (6.4) 30 (2.8) 102 (9.4) 65 (6.0) 7 (0.6) |
23 (7.7) 13 (4.3) 8(2.7) 19 (6.3) 7 (2.3) 2 (0.7) |
<0.001 0.022 0.003 <0.001 <0.001 0.431 |
Psychological side effect Sleep disturbance Anxiety and stress Depression |
110 (10.1) 68 (6.3) 48(4.4) |
22 (6.7) 8 (2.4) 6 (1.8) |
<0.001 0.003 0.007 |
Irregular menses (Females) | 17 (1.6) | 4 (1.3) | 0.861 |
Decreased libido | 14 (1.3) | 5 (1.6) | 0.264 |
Lymph node enlargement and swelling | 12 (1.1) | 4 (1.3) | 0.044 |
Eye symptoms Blurred vision |
40 (3.7) | 8 (2.7) | 0.011 |
Skin itching Acne Sweating |
29 (2.7) 22 (2.0) 76 (7.0) |
6 (2.0) 5 (1.6) 11 (3.7) |
0.209 0.978 0.001 |
Increase urination Change urine color |
16 (1.5) 11 (1.0) |
2 (0.7) 2 (0.7) |
0.428 0.985 |
Cardiac side effect Shortness of breath Palpitation Chest pain Loss of consciousness Paleness Bleeding anywhere |
76 (7.0) 93 (8.6) 56 (5.2) 7 (0.6) 35 (3.2) 5 (0.5) |
21 (7.0) 10 (3.3) 11 (3.7) 0 (0.0) 6 (2.0) 0 (0.0) |
0.017 0.010 0.023 0.362 0.311 0.167 |
Dizziness | 157 (14.5) | 27 (9.0) | <0.001 |