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. 2021 Oct 6;18(1):1981086. doi: 10.1080/21645515.2021.1981086

Table 3.

Side effect after receiving vaccines related to gender

Symptoms After 1st dose of COVID-19 vaccineFrequency (%)
p Value After 2nd dose of COVID-19 vaccineFrequency (%)
p Value
Female N = 684 Male N = 402 Female N = 211 Male N = 109
Presence
No
Yes
53 (7.7)
631 (92.3)
57 (14.2)
345(85.8)
0.001 54(25.6)15
7 (74.4)
18(16.5)
91 (83.5)
0.065
Injection site pain
Redness and swelling
568 (83.0)
129 (18.9)
283 (70.4)
48 (11.9)
<0.001
0.003
125 (59.2)
33 (15.6)
75 (68.8)
12 (11.0)
0.872
0.142
Bone and muscle pain 264 (38.6) 144 (35.8) 0.362 57 (35.5) 28 (25.6) 0.418
Flu like symptoms
Fever
Headache
Chills
Sore throat
fatigue
cough
runny nose
loss of taste
loss of smell
174(25.4)
248 (36.3)
244 (35.7)
73 (10.7)
381 (55.8)
70 (10.2)
58 (8.5)
12 (1.8)
14 (2.0)
126 (31.3)
111 (27.6)
107 (26.6)
17 (4.2)
182 (45.3)
21 (5.2)
18 (4.5)
2 (0.5)
2 (0.5)
0.036
0.003
0.002
<0.001
0.004
0.013
0.076
0.041
38(18.0)
45(21.3)
47(22.2)
15(7.1)
85(40.2)
7(3.3)
8 (3.7)
2 (0.9)
3 (1.4)
19 (17.4)
14(12.8)
22(20.1)
3 (2.7)
36 (33.0)
3(2.7)
6 (5.5)
0 (0.0)
0 (0.0)
0.554
0.030
0.362
0.071
0.079
0.644
0.649
0.278
0.184
GI side effect
Nausea
Diarrhea
Vomiting
loss of appetite
abdominal pain
constipation
127(18.6)
52(7.6)
18(2.6)
74 (11.1)
53 (7.7)
6 (0.9)
37 (9.2)
18(4.5)
12(3.0)
28 (7.2)
12 (3.0)
1 (0.2)
<0.001
0.043
0.731
0.039
0.001
0.211
16 (7.5)
9(4.2)
7 (3.3)
14(6.6)
4 (1.8)
1 (0.4)
7 (6.4)
4(3.6)
1 (0.9)
5(4.5)
3 (2.7)
1 (0.9)
0.509
0.639
0.149
0.330
0.748
0.703
Psychological SE
Sleep disturbance
Anxiety and stress
Depression
74 (10.8)
47 (6.9)
35 (5.1)
36 (9.0)
21 (5.2)
13 (3.2)
0.326
0.279
0.145
17(8.0)
6(2.8)
4(1.8)
5(4.5)
2(1.8)
1(0.9)
0.161
0.480
0.430
Irregular menses 17 (2.5) 0 (0.0) 0.001 4 (1.8) 0 (0.0) 0.125
Decreased libido 4 (0.6) 10 (2.5) 0.007 4(1.8) 1(0.9) 0.430
Lymph node enlargement & swelling 8 (1.2) 4 (1.0) 0.790 2(0.9) 2 (1.8) 0.590
Skin itching
Acne
Sweating
26(3.8)
20 (2.9)
45 (6.6)
3 (0.7)
2 (0.5)
31 (7.7)
0.003
0.006
0.480
5 (2.3)
5 (0.7)
9 (4.2)
1 (0.9)
0 (0.0)
2 (1.8)
0.301
0.086
0.193
Increase urination
Change urine color
9 (1.3)
6 (0.9)
7 (1.7)
5 (1.2)
0.574
0.560
1 (0.1)
2(0.3)
1 (0.2)
0 (0.0)
0.703
0.278
Blurred vision 30 (4.4) 10 (2.5) 0.109 8 (1.2) 0 (0.0) 0.030
Cardiac side effects
Shortness of breath
Palpitation
Chest pain
Loss of consciousness
Paleness
Bleeding anywhere
56 (8.2)
72 (10.5)
39 (5.7)
4 (0.6)
24 (3.5)
4 (0.6)
20 (5)
21 (5.2)
17 (4.2)
3 (0.7)
11 (2.7)
1 (0.2)
0.045
0.003
0.289
0.748
0.486
0.430
14 (6.6)
6 (2.8)
8 (3.7)
0 (0.0)
5 (0.7)
0 (0.0)
7 (6.4)
4(3.6)
3(2.7)
0 (0.0)
1 (0.2)
0 (0.0)
0.724
0.844
0.501

0.301
Dizziness 119 (17.4) 38 (9.5) <0.001 20 (9.4) 7 (6.4) 0.227
Require hospitalization 0 (0.0) 0 (0.0) 0.260 2 (1.0) 0 (0.0) 0.241
Onset of Symptoms
Immediately
1st day
1st week
2nd week
3rd week
69(11.0)
506(80.7)
44 (7.0)
6(1.0)
2(0.3)
26 (7.9)
275 (83.1)
24 (7.3)
4 (1.2)
2 (0.6)
0.577 20(11.4)
120(68.2)
16(9.1)
19(10.8)
0 (0.0)
7(6.9)
70(68.6)
5(4.9)
19(18.6)
1(1)
0.153
Duration of Symptoms
mean (SD)
2.32(2.3) 2.64 (4.5) 0.082 2.82 (3.74) 2.54 (4.1) 0.354

N: population size, SD: standard deviation.