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. 2022 Mar 15;132(6):e142137. doi: 10.1172/JCI142137

Figure 6. Arginine availability modulates microglial polarization.

Figure 6

(A) Schematic representation of hypothesized microglial activation and polarization by arginine availability. (B–E) qPCR analysis of Arg1, iNOS, Ym1, and Tnfa expression levels in tumor tissue. (F–I) Immunohistochemical assessment and quantification of microglial Arg1 and iNOS levels by Iba-1/Arg1 and Iba-1/iNOS costaining of free-floating sections. Scale bars: 100 μm. Data were analyzed using 1-way ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. NS, not significant.