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. 2022 Mar 15;132(6):e142137. doi: 10.1172/JCI142137

Figure 9. ADI-PEG20 combined with ionizing radiation eradicates CT-2A orthotopic GBM tumors.

Figure 9

(A) Bioluminescence imaging (BLI) of intracranial tumors in mice using an IVIS Spectrum in vivo imaging system and Living Image software starting from day 5 after injection of CT-2A tumor cells. (B) Kaplan-Meier survival graph. Animals administered combined treatment remained healthy and tumor free at time of harvest. Three mice in each treatment group were additionally analyzed by MRI at early (5 days), mid (14 days), and late (16 days for ADI animals and 18 days for other groups) time points after intracranial injection of cells, and additional images were obtained for animals in the combination group. ADI animals were imaged earlier because they showed signs of distress. (C and D) Representative MR and BL images of mice in each group. (E) Box-and-whisker plot of the calculated T1 tumor volumes at early, mid, and late MRI time points.