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. 2022 Mar 15;132(6):e149828. doi: 10.1172/JCI149828

Figure 1. Weekly prednisone improved muscle performance in both male and female mice.

Figure 1

(A) C57BL/6J mice were treated for 4 weeks with vehicle (DMSO) or weekly or daily prednisone, and then analyzed. (B–F) Weekly treated mice exhibited significantly increased maximal tetanic force (B) and specific force (C) and reduced contraction (D) and relaxation (E) time compared with vehicle-treated mice. Once-weekly prednisone–treated mice also exhibited increased response to repetitive force (F) compared with vehicle-treated mice. (G and H) Weekly treated mice had increased concentrations of ATP (G) and NAD+ (H) compared with vehicle-treated animals, while daily treated mice had significantly reduced concentrations. Data were analyzed with 1-way ANOVA (B–E, G, and H) or 2-way ANOVA (F).