Skip to main content
. 2022 Mar 15;132(6):e149828. doi: 10.1172/JCI149828

Figure 10. Sex-specific GR binding patterns in skeletal muscle treated with weekly prednisone.

Figure 10

(A) ChIP-qPCR showed low occupancy of GR at a negative control locus on chromosome 5 (desert) and high occupancy at the canonical GRE near Fkbp5 in both males and females. Putative GREs near lipid metabolism genes had increased occupancy of GR in weekly treated females compared with vehicle-treated females; males had no change in GR occupancy. (B and C) ChIP-qPCR showed increased occupancy at putative GREs near IGF1/PI3K pathway (B) and calcium-handling (C) genes in weekly treated males, while females had no change in binding with treatment. Data were analyzed with Welch’s t test (A–C).