Figure 7. Weekly prednisone–treated females had increased glyceride catabolism and mitochondrial phospholipid abundance.

(A) Muscles (quadriceps) from weekly prednisone–treated females had significantly increased expression of enzymes involved in triglyceride catabolism and acyl-CoA synthesis. (B) Females also had significantly reduced abundance of triglyceride and diglyceride species in the quadriceps. (C) Enzymes involved in phosphatidylcholine synthesis were significantly upregulated by weekly prednisone treatment. (D) Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) abundance was increased in weekly prednisone–treated females compared with vehicle-treated females. Top 3 most abundant lipid compounds are presented as (number of carbon atoms):(number of double bonds); less abundant compounds are listed in Supplemental Table 4. Data were analyzed with Mann-Whitney test (A and C) or Welch’s t test (B and D).