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. 2022 Mar 15;132(6):e153454. doi: 10.1172/JCI153454

Figure 1. The hIgG1-G396R variant protects against colorectal tumorigenesis and progression.

Figure 1

(A) Survival analyses of 1006 CRC patients with available follow-up information stratified by genotype. WT is indicated as the CC genotype, hIgG1-G396R heterozygous is denoted as CT, and hIgG1-G396R homozygous is denoted as TT. (B and C) Survival curves for 1006 CRC patients, classified by (B) recessive model and (C) dominant model. (D and E) Forest plots showing hazard ratios by (D) univariable COX regression and (E) multivariable COX regression analysis for correlation with the OS of CRC patients. (F–I) OS curves of 1006 CRC patients with different clinical treatments and clinical manifestations. Statistical significance was determined using a log-rank test (A–C and F–I). HR, hazard ratio; CI, confidence interval. Data are presented as the mean ± SEM.