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(a) The experimental region of Mixture components defined by the constraints: 160 ≤ A ≤ 220, 40 ≤ B ≤ 100 and 60 ≤ C ≤ 120, where A = Span 20 amount (mg), B = Cholesterol amount (mg), and C = Cremophor RH amount (mg), (b) Design points over the constrained mixture region; where: o single trial, ● replicated trial, and □ optimized formula.
