Table 2.

(b) Predicted values of different responses for the optimized formula compared with the actual values of its two replicated design points (S4 and S12) together with the prediction intervals and percent deviations.

b)
	Predicted values for optimized formula	Two sided 95% prediction interval		Prepared Formulae	Actual values	Percent Deviation
Response		Low	High
PS	201.1	157.4	278.3	S4	190.2	5.4
				S12	213.9	6.4
ZP	−38.4	−43.4	−33.5	S4	−39.3	2.2
				S12	−39.0	1.4
EE	85.1	81.5	88.7	S4	85.7	0.7
				S12	84.7	0.5

Coeff: Coefficient, RMSE: Root mean square error, CV%: Coefficient of variation percent, R²: Regression coefficient, PS: Particle size (nm), ZP: Zeta potential (mV), EE: Entrapment efficiency (%).

*p-values for significant terms are marked by an asterisk.