Table 1.

Pharmacokinetic parameters of BBR after oral and intravenous administration in rats ($\overline{x}$ ± $s_{\overline{x}}$) (n = 8).

Parameters	Oral administration (400 mg/kg)	Intravenous administration (2.5 mg/kg)
AUC0–t (μg/mL*h)	0.681 ± 0.093	6.422 ± 0.685
AUC0–∞ (μg/mL*h)	0.685 ± 0.093	7.438 ± 0.548
MRT (h)	4.525 ± 0.515	5.600 ± 0.561
t1/2z (h)	3.136 ± 0.357	3.885 ± 0.389
Tmax (h)	1.000 ± 0.000	–
Clz/F (L/h/kg)	253.89 ± 10.510	131.430 ± 2.513
Cmax/C0 (μg/mL)	0.260 ± 0.032	2.833 ± 0.132