Table 2.
Ce/p of BBR determined in rats following intraperitoneal injection at the dose of 2.5 mg/kg.
| Time (min) | Rats no. | Ce (μM) | Cp (μM) | Ce/p |
|---|---|---|---|---|
| 5 | 1 | 1.313 | 0.000 | ∞ |
| 2 | 0.039 | 0.489 | 0.081 | |
| 3 | 0.000 | 0.000 | – | |
| 4 | 0.375 | 0.233 | 1.610 | |
| 5 | 0.862 | 0.233 | 3.700 | |
| 6 | 0.584 | 0.416 | 1.405 | |
| 30 | 1 | 0.539 | 0.616 | 0.875 |
| 2 | 0.044 | 0.000 | ∞ | |
| 3 | 0.000 | 0.000 | ∞ | |
| 4 | 0.212 | 0.000 | ∞ | |
| 5 | 0.026 | 0.282 | 0.090 | |
| 6 | 0.176 | 0.197 | 0.897 | |
| 120 | 1 | 0.225 | 0.000 | ∞ |
| 2 | – | 1.243 | – | |
| 3 | 0.000 | 0.000 | ∞ | |
| 4 | 0.000 | 0.000 | ∞ | |
| 5 | 0.000 | 0.000 | ∞ | |
| 6 | 0.132 | 0.000 | ∞ |
Ce: Drug concentration in erythrocytes, Cp: Drug concentration in plasma, Ce/p: Erythrocytes/plasma partition coefficient. ∞: Infinity.