TABLE 1.
MICs, percent hyphal formation, and mechanisms of resistance of C. albicans isolates
| Strain designation
|
MIC (μg/ml)
|
% Hyphal formation in the presence of the following:
|
Mechanism(s) of resistance
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Series | This study | Previous publication | Fluconazole | Ketoconazole | Fluconazole (10 μg/ml) | Ketoconazole (2 μg/ml) | Increased MDR1 mRNA levels | Increased ERG11 mRNA levels | ERG11 R476K point mutation | Increased CDR mRNA levels |
| Series 1a | A1 | 1 | 0.25 | 0.010 | 0 | 6 | − | − | − | − |
| A2 | 4 | 8 | 0.023 | 29 | 17 | +++ | − | − | − | |
| A3 | 12 | 16 | 0.028 | 79 | 41 | +++ | + | − | − | |
| A4 | 13 | 32 | 0.056 | 88 | 86 | +++ | + | + | − | |
| A5 | 17 | >64 | 0.624 | 93 | 93 | +++ | + | + | ++ | |
| Series 2b | B1 | 1 | 2 | 0.03 | 5 | 21 | − | − | − | + |
| B2 | 3 | 8 | 0.25 | 77 | 86 | − | − | − | ++ | |
| B3 | 5 | 64 | 0.25 | 96 | 85 | − | − | − | +++ | |
| B4 | 8 | 16 | 0.25 | 92 | 85 | − | − | − | ++ | |
| B5 | 9 | 1 | 0.03 | 0 | 31 | − | − | − | + | |