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Non-tumorous adrenal cortical atrophy. In the absence of exogenous cortisol intake, the presence of adrenal cortical atrophy in the non-tumorous adrenal cortex is a hallmark of adrenal Cushing syndrome due to an autonomous cortisol-secreting adrenal cortical neoplasms. Reduced adrenal cortical thickness (< 2 mm) in association with significantly reduced to absent zona reticularis layer is a diagnostic feature of adrenal cortical atrophy
