Fig. 25.
Atypical mitotic figures in adrenal cortical carcinomas. Atypical mitotic figure is a component of several multiparametric diagnostic schemes in adrenal cortical neoplasia. In the Lin–Weiss–Bisceglia system, it is one of the major criteria that would warrant a diagnosis of oncocytic adrenal cortical carcinoma. This photomicrograph illustrates atypical mitotic figures in an oncocytic adrenal cortical carcinoma. This tumor had also an increased mitotic activity (> 5 per 10 mm2) and angioinvasion, and Ki67 labeling index > 15% (not shown)