TABLE 3.
Associations of age‐related DNA methylation on ChrY with all‐cause mortality in the validation stage
| CpG | Position | Mapped Gene | Relation to Gene | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | ||||
| cg01707559 | 6778695 | TBL1Y | TSS200 | 1.06 | (0.81, 1.40) | 6.80E−01 | 1.08 | (0.82, 1.43) | 5.75E−01 |
| cg03441493 | 14074417 | 1.35 | (1.05, 1.74) | 2.65E−02 | 1.37 | (1.04, 1.79) | 2.48E−02 | ||
| cg09093035 | 14074689 | 0.97 | (0.75, 1.25) | 8.11E−01 | 0.97 | (0.74, 1.28) | 8.33E−01 | ||
| cg03258315 | 14077975 | 1.21 | (0.92, 1.59) | 1.63E−01 | 1.20 | (0.93, 1.54) | 4.90E−01 | ||
| cg09730640 | 14533708 | 0.99 | (0.76, 1.31) | 9.80E−01 | 0.95 | (0.71, 1.28) | 7.56E−01 | ||
| cg25032547 | 14773536 | TTTY15 | TSS1500 | 0.86 | (0.67, 1.11) | 2.58E−01 | 0.84 | (0.65, 1.09) | 1.93E−01 |
| cg17816615 | 15019332 | DDX3Y | Body | 0.70 | (0.54, 0.93) | 1.21E−02 | 0.70 | (0.54, 0.93) | 1.25E−02 |
| cg26198148 | 15814685 | TMSB4Y | TSS1500 | 0.94 | (0.73, 1.22) | 6.25E−01 | 0.92 | (0.72, 1.19) | 5.44E−01 |
| cg04691144 | 16634373 | NLGN4Y | TSS1500 | 0.96 | (0.75, 1.24) | 7.90E−01 | 0.99 | (0.77, 1.27) | 9.31E−01 |
| cg27443332 | 16634795 | NLGN4Y | Body | 0.81 | (0.62, 1.08) | 1.50E−01 | 0.83 | (0.63, 1.10) | 1.83E−01 |
| cg03706273 | 16635745 | NLGN4Y | 1stExon | 0.97 | (0.74, 1.28) | 8.25E−01 | 0.97 | (0.74, 1.28) | 8.30E−01 |
| cg03244189 | 21238472 | TTTY14 | Body | 0.90 | (0.70, 1.17) | 4.26E−01 | 0.92 | (0.72, 1.19) | 5.22E−01 |
| cg13845521 | 21238886 | TTTY14 | Body | 0.98 | (0.74, 1.29) | 8.76E−01 | 0.96 | (0.72, 1.29) | 7.62E−01 |
| cg11816202 | 21239332 | TTTY14 | TSS200 | 1.16 | (0.90, 1.50) | 2.77E−01 | 1.17 | (0.88, 1.53) | 2.82E−01 |
| cg15345074 | 21239461 | TTTY14 | TSS200 | 0.91 | (0.69, 1.20) | 5.00E−01 | 0.91 | (0.69, 1.20) | 5.25E−01 |
| cg01988452 | 22736528 | EIF1AY | TSS1500 | 0.99 | (0.75, 1.30) | 9.40E−01 | 1.03 | (0.78, 1.36) | 8.11E−01 |
| cg13308744 | 22736584 | EIF1AY | TSS1500 | 1.03 | (0.80, 1.33) | 8.13E−01 | 1.03 | (0.78, 1.36) | 8.44E−01 |
| cg14467015 | 23757241 | TTTY13 | TSS1500 | 0.92 | (0.70, 1.21) | 5.49E−01 | 0.87 | (0.65, 1.17) | 3.46E−01 |
| Weighted MRS | 1.15 | (0.72, 1.83) | 5.57E−01 | 1.20 | (0.75, 1.92) | 4.48E−01 | |||
Model 1 was adjusted for age, BMI, smoking status, and alcohol drinking status. Model 2 was additionally adjusted for education level, physical activity, and consumption of meat, vegetables, and fruits. Weighted MRS was calculated as the sum of coefficient multiplied by methylation level of each age‐related CpG.