Fig. 4.
Binding mode and structure of covalent peptidomimetic inhibitors with a γ-lactam (colored red) or α-ketoamide (colored dark green) moiety, based on available co-crystallization PDB structures in the active site of SARS-CoV-2 Mpro. Catalytic residues are colored (His41: green, Cys145: yellow). Important residues for binding are shown in sticks and hydrogen bonds are depicted as yellow dashes. The PDB ID for each inhibitor is indicated in Table 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)