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. 2022 Mar 8;49(5):58. doi: 10.3892/ijmm.2022.5114

Table IV.

Correlation between the SHH, GLI TFS, and their targeted genes at the mRNA levelsa.

Genes
GLI2
GLI3
GLI1
Correlation results rb P-valueb rb P-valueb rb P-valueb
SHH 0.600 <0.0001 0.644 <0.0001 0.680 <0.0001
GLI1 0.767 <0.0001 0.894 <0.0001 - -
PTCH1 0.560 0.0002 0.548 0.0003 0.577 0.0002
BCL2 0.649 <0.0001 0.517 0.0003 0.628 <0.0001
MYC 0.696 <0.0001 0.600 <0.0001 0.526 0.0002
VEGFA 0.752 <0.0001 0.771 <0.0001 0.755 <0.0001
CCND1 0.333 0.038 0.188 0.239 0.164 0.306
a

GLI TFs are placed horizontally; SHH and the affected genes are vertical.

b

r and P-values were calculated by Spearman's test: results with statistically significant values are indicated in bold print. SHH, sonic hedgehog; PTCH1, patched 1; GLI1,2,3, glioma-associated zinc finger protein 1, 2, 3; BCL2, BCL2 apoptosis regulator; MYC, MYC proto-oncogene; TFs, transcription factorS; VEGFA, vascular endothelial growth factor A; CCND1, cyclin D1.