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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Cytotherapy. 2021 Mar 26;23(5):411–422. doi: 10.1016/j.jcyt.2020.04.102

Figure 5.

Figure 5.

Effects of NK cells and B lymphocytes on MSC engraftment. (A) NK cells were depleted with ASGM1 antibody in spleen. (B) NK cell depletion did not have any impact on splenic macrophage levels. (C) MSC migration was analyzed on day 1, day 2, day 5, day 8 and day 11 by bioluminescence imaging and compared with NK cell non-depleted and control groups. Bioluminescence signal was quantified and analyzed in the tumor regions. (D) MSC migration was analyzed in SCID and nude mouse models. On day 1, day 3, day 5, day 7, day 10, day 12 and day 14 after MSC injection, animals were imaged using Xenogen IVIS, and MSC signal was analyzed in tumor regions, comparing each experimental cohort with their own strain-specific controls. Data were analyzed using a linear mixed-effects model and post hoc pairwise comparisons. Tukey-adjusted Pvalues were used to determine significance. *P< 0.05, **P< 0.01, ****P< 0.0001. ASGM1, anti-asialo GM1; IVIS, in vivo imaging system.