TABLE 1.

Distribution of MICs of pexiganan for aerobic bacteria

Microorganism	No. of isolates	No. of strains for which the MIC (μg/ml) is as follows:												MIC (μg/ml)
		≤0.25	0.5	1	2	4	8	16	32	64	128	256	>256	50%	90%
Aerobes
Gram-positive aerobes
Staphylococcus aureus	512				6	53	332	93	24	4				8	16
Staphylococcus epidermidis	137			1	54	45	28	8		1				4	8
Staphylococcus haemolyticus	50				10	24	12	4						4	8
Other coagulase-negative staphylococcia	117				14	43	54	3	1	2				8	8
Streptococcus agalactiae	105					48	35	13	9					8	16
Streptococcus pyogenes	253				118	95	28	8	1	1	2			4	8
Streptococcus sanguis	30				1	1	4	2	1	6	4	3	8	64	>256
Other streptococcic	83	1				16	32	26	5	2			1	8	16
Enterococcus faecalis	101				1			1	6	13	37	32	11	128	>256
Enterococcus faeciumb	10					9		1						4	4
Micrococcus spp.	37				10	8	15	4						4	8
Corynebacterium spp.d	49	2			6	31	6	3	1					4	8
Gram-negative aerobes
Acinetobacter baumanii	113			13	49	38	13							2	8
Alcaligenes faecalis	24	2				1	5	5	2	2	4	1	2	16	256
Citrobacter diversus	78					7	53	16	1				1	8	16
Citrobacter freundii	105					4	72	29						8	16
Enterobacter aerogenes	102						23	63	13	3				16	32
Enterobacter cloacae	117					3	37	48	13	7	5	2	2	16	64
Escherichia coli	137			2	6	13	37	54	20	5				16	32
Klebsiella oxytoca	100					3	46	44	5	1	1			16	16
Klebsiella pneumoniae	123				4	47	55	15	1	1				8	16
Pseudomonas aeruginosa	150				1	20	45	58	18	6	2			16	32
Other Pseudomonas spp.e	35					9	16	8					2	8	16
Stenotrophomonas maltophilia	124				10	31	56	22	5					8	16
Anaerobes
Gram-positive anaerobes
Clostridium innocuum	26	1				5	11	6	1	1	1			8	16
Clostridium perfringens	31			7		4	3	7	5	2		3		16	64
Clostridium ramosum	24				1	11	9	3						4	16
Clostridium sporogenes	20					6	9	5						8	16
Peptostreptococcus anaerobius	23	1			5	2	7	4	2		1	1		8	32
Peptostreptococcus magnus	29	2	1	3	8	9	3	1		1		1		2	8
Peptostreptococcus prevotii	25	2		8	7	6	2							2	4
Propionibacterium acnes	33			3	6	18	4	2						4	8
Gram-negative anaerobes
Bacteroides distasonis	30		1	2	8	17	2							4	4
Bacteroides fragilis	34	1	1		11	19	1	1						4	4
Bacteroides ovatus	20					17	2	1						4	8
Bacteroides thetaiotaomicron	35	1		1	12	13	5	1				1	1	4	8
Fusobacterium nucleatum	29			3		9	6		6	3			2	8	64
Prevotella bivia	35	1			1	17	3	4	7		2			4	32
Prevotella melaninogenica	22			1	4	9	2		3	1	2			4	64
Total	3,108	14	3	44	353	711	1,073	563	150	62	61	44	30

^aIncludes 32 Staphylococcus hominis, 30 Staphylococcus simulans, 27 Staphylococcus warneri, and 27 Staphylococcus xylosus isolates and 1 Staphylococcus intermedius isolate. 

^bAll isolates were vancomycin resistant (MIC, >32 μg/ml). 

^cIncludes 38 Streptococcus bovis (group D), 11 Streptococcus group C, and 29 Streptococcus group G isolates, 1 Streptococcus salivarius isolate, 3 Streptococcus equisimilis isolates, and 1 Streptococcus mitis isolate. 

^dIncludes 24 Corynebacterium xerosis, 10 C. minutissimum, 7 C. striatum, 3 Corynebacterium group ANF, 2 Corynebacterium group B, and 2 Corynebacterium group G2 isolates and 1 Corynebacterium group I isolate. 

^eIncludes 17 Pseudomonas fluorescens, 10 Pseudomonas putida, 2 Pseudomonas stutzeri, 2 Pseudomonas pickettii, and 2 Pseudomonas species isolates and 1 isolate each of Pseudomonas paucimobilis and Pseudomonas vesicularis.