TABLE 5.

Comparison of the difference between MIC and MBC of pexiganan for aerobic bacteria

Organism	No. of isolates	No. of isolates for which the MIC was different from the MBC by the following no. of doubling dilutionsa:
		0	+1	+2	+3	≥+4
Staphylococcus aureus	5	3	1		1
Coagulase-negative staphylococcib	25	22	3
Streptococcus agalactiae	5	5
Streptococcus pyogenes	5	3		1	1
Other streptococcic	23	14	5	1	1	2
Enterococcus faecalis	4	2	1	1
Micrococcus spp.	4	4
Corynebacterium spp.d	9	9
Enterobacteriaceaee	35	25	9	1
Pseudomonas spp.f	10	6	4
Acinetobacter baumannii	5	5
Stenotrophomonas maltophilia	5	5
Alcaligenes faecalis	8	3	3	2
Total	143	106	26	6	3	2
Cumulative %		74	92	97	99	100

^aThe difference between the MIC and the MBC was present as follows: 0, the MBC equals the MIC; +1, the MBC is 1 doubling dilution higher than the MIC; +2, the MBC is 2 doubling dilutions higher than the MIC; +3, the MBC is 3 doubling dilutions higher than the MIC; ≥+4, the MBC is 4 doubling dilutions or more than four doubling dilutions higher than the MIC. 

^bIncludes five Staphylococcus epidermidis, five Staphylococcus haemolyticus, three Staphylococcus hominis, four Staphylococcus simulans, four Staphylococcus warneri, and four Staphylococcus xylosus isolates. 

^cIncludes three Streptococcus bovis, five Streptococcus group C, three Streptococcus group G, seven Streptococcus intermedius, and five Streptococcus sanguis isolates. 

^dIncludes five Corynebacterium minutissimum and three Corynebacterium striatum isolates and one Corynebacterium xerosis isolate. 

^eIncludes five Citrobacter freundii, four Citrobacter koseri, five Enterobacter aerogenes, six Enterobacter cloacae, five Escherichia coli, five Klebsiella oxytoca, and five Klebsiella pneumoniae isolates. 

^fIncludes five Pseudomonas aeruginosa and five Pseudomonas fluorescens isolates.