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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Cancer Genet. 2022 Jan 5;262-263:53–56. doi: 10.1016/j.cancergen.2022.01.001

Figure 1. Representative hematoxylin and eosin (H&E)-stained images of the SLCT lesions with corresponding DICER1 alterations.

Figure 1.

A. H&E image of RT1 (10x magnification) highlighting tumor with bland enteric-type heterologous epithelium adjacent to tubular and cystic structures.

B. H&E image of LT1 (10x magnification) demonstrating sheets of dark cells with angulated nuclei and moderate clear cytoplasm. No heterologous elements were present.

C. H&E image of LT2 (10x magnification) showing fascicles of spindle cells with oval nuclei and eosinophilic cytoplasm (top) consistent with poorly differentiated Sertoli-Leydig cell tumor. Focal well-differentiated area showing tubular structures was present (bottom).

D. Integrative Genomics Viewer (IGV) view of the 3 different somatic missense mutations and the germline variant in DICER1 as seen in each tumor and blood, respectively. Each somatic variant is unique to each tumor specimen, and the germline variant is present in all specimens.

RT1, right ovary tumor; LT1, left ovary tumor #1; LT2, left ovary tumor #2.