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. 2022 Mar 18;43(2):150–165. doi: 10.24272/j.issn.2095-8137.2021.363

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Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Application of CAR-Treg cells in animal model of colitis

Two CAR-Tregs have been applied in colitis. TNP-TPCR Tregs express a TNP-specific scFv, which is fused to the extracellular and transmembrane domain of CD28 co-stimulatory molecule and intracellular domain of stimulatory Fc-γ receptor chain. TNP-TPCR Tregs have been applied in hapten-mediated colitis mouse models, which are induced by TNBS or oxazolone (Elinav et al., 2008). CEA-CAR-Tregs express CEA-SCA431 CAR signaling domains fused with CD28-CD3ζ in CD4⁺CD25⁺ Treg cells. CEA-CAR-Tregs have been applied in dextran sulfate sodium (DSS)-induced colitis mouse models (Tanaka et al., 2003). TNP: 2,4,6-trinitrophenol; TPCR: Tripartite chimeric receptor; scFv: Single chain antibody fragment; CEA: Carcinoembryonic antigen.