Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 18;43(2):150–165. doi: 10.24272/j.issn.2095-8137.2021.363

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Application of CAR-T cells in animal model of RA

RA produces autoantibodies that cause joint swelling and systemic inflammation. Methods for eliminating autoimmune B cells by CAR-T are as follows: first, autoantibody type is determined by ELISA, and then anti-FITC CAR-T and FITC-labeled autoantibody-positive peptides are prepared to eliminate autoreactive B cells under peptide-mediated CAR-T toxicity in mice. In vitro experiments have shown that anti-FITC CAR-T cells recognize and kill anti-COII antibody-secreting B cells from CIA mice by binding with an antigenic FITC-conjugated peptide. CIA mice are RA mice induced by type II collagen and CFA. DBA/1 mice are commonly used (Kannan et al., 2005). RA: Rheumatoid arthritis; ELISA: Enzyme-linked immunosorbent assay; FITC: Fluorescein isothiocyanate; CIA: Collagen-induced arthritis; CFA: Complete Freund’s adjuvant.