Table 4.
Clinical features associated with four different HCoVs (n = 84).
| Total (n = 84) |
OC43 (n = 25) |
NL63 (n = 26) |
HKU1 (n = 23) |
229E (n = 16) |
|
|---|---|---|---|---|---|
| Median [IQR] /number (%) |
Median [IQR] /number (%) |
Median [IQR] /number (%) |
Median[IQR] /number (%) |
Median [IQR] /number (%) |
|
| Age (Months) | 16.5 [7.0–38.3] | 12.0 [5.0–29.0] | 16.5 [7.5–23.8] | 34 [9.5–46.5] | 18 [7.5–43.8] |
| <2 months | 8 (9.5) | 3 (12.0) | 1 (3.8) | 3 (13.0) | 3 (18.8) |
| 2–5 months | 10 (11.9) | 4 (16.0) | 4 (15.4) | 1 (4.3) | 1 (6.3) |
| 6–11 months | 11 (13.1) | 5 (20.0) | 4 (15.4) | 2 (8.7) | 1 (6.3) |
| 12–23 months | 23 (27.4) | 6 (24.0) | 10 (38.5) | 4 (17.4) | 4 (25.0) |
| >24 months | 32 (38.1) | 7 (28.0) | 7 (26.9) | 13 (56.5) | 7 (43.8) |
| Sex (male) | 52 (61.9) | 16 (64.0) | 18 (69.2) | 16 (69.6) | 6 (37.5) |
| Period from onset to hospitalization (day) | 3 [1–5] | 3 [1–4] | 2.5 [1.3–4] | 4 [1–5] | 2 [2–4] |
| Hospitalization period (day) | 4 [4–5] | 4 [4–5] | 4 [3–5] | 5 [4–6] | 4.5 [4–6.3] |
| Fever | 74 (88.1) | 18 (72.0) | 24 (92.3) | 21 (91.3) | 14 (87.5) |
| Rhinorrhea | 53 (63.1) | 20 (80.0) | 11 (42.3) | 18 (78.3) | 9 (56.3) |
| Cough | 77 (91.7) | 24 (96.0) | 25 (92.3) | 20 (87.0) | 14 (87.5) |
| Wheezing | 23 (27.4) | 4 (16.0) | 8 (30.8) | 7 (30.4) | 5 (31.3) |
| WBC (/μL) | 10400 [7350–14275] | 10400 [7800–12200] | 8650 [7225–13675] | 9100 [6700–15500] | 11150 [8650–14375] |
| CRP (mg/dL) |
1.1 [0.3–2.6] |
0.8 [0.3–1.7] |
1.0 [0.5–2.5] |
1.2 [0.3–2.2] |
0.9 [0.4–2.9] |
| Diagnosis | |||||
| Tympanitis | 4 (4.8) | 1 (4.0) | 1 (3.8) | 2 (8.7) | 0 (0.0) |
| URI | 19 (22.6) | 4 (16.0) | 10 (38.5) | 3 (13.0) | 3 (18.8) |
| Croup | 7 (8.3) | 0 (0.0) | 7 (26.9) | 0 (0.0) | 0 (0.0) |
| LRI |
59 (70.2) |
18 (72.0) |
15 (57.7) |
18 (78.3) |
11 (68.8) |
| Single virus detection | 35 (41.7) | 9 (36.0) | 11 (42.3) | 10 (43.5) | 2 (12.5) |
| Multiple virus detection |
49 (58.3) |
16 (64.0) |
15 (57.7) |
13 (56.6) |
14 (87.5) |
| RSV (A, B) | 21 (25.0) | 7 (28.0) | 8 (30.8) | 2 (8.7) | 5 (31.3) |
| Flu (A, B, C) | 3 (3.6) | 1 (4.0) | 1 (3.8) | 1 (4.3) | 0 (0.0) |
| HCoV (HKU1, OC43, 229E, NL63) | 6 (7.1) | 4 (16.0) | 2 (7.7) | 2 (8.7) | 3 (18.8) |
| hMPV | 10 (20.4) | 1 (4.0) | 2 (7.7) | 5 (21.7) | 2 (12.5) |
| HPIV (1, 2, 3, 4) | 3 (6.1) | 0 (0.0) | 0 (0.0) | 2 (8.7) | 1 (6.3) |
| ADV (2, 4) | 11 (13.1) | 4 (25.0) | 4 (15.4) | 1 (4.3) | 1 (6.3) |
| HboV | 12 (14.3) | 3 (12.0) | 4 (15.4) | 3 (13.0) | 2 (12.5) |
| HRV | 10 (11.9) | 2 (8.0) | 2 (7.7) | 3 (13.0) | 3 (18.8) |
Data are shown as median (IQR) or numbers (%).
IQR, interquartile range; WBC, white blood cell; CRP, C-reactive protein; PICU, pediatric intensive care unit; URI, upper respiratory infection; LRI, lower respiratory infection; RSV, respiratory syncytial virus; Flu, influenza virus; HCoV, hMPV, human metapneumovirus; HPIV, human parainfluenza virus; ADV, adenovirus; HBoV, human bocavirus; and HRV, human rhinovirus.