Table 5.

Comparison of clinical characteristics among patients with RSV monoinfection, HCoV monoinfection, and RSV and HCoV co-infection.

	RSV (n = 362)	HCoV (n = 35)	RSV + HCoV (n = 9)
	Median [IQR]/number (%)	Median [IQR]/number (%)	Median [IQR]/number (%)	PA	PB	PC	PD
Age (Months)	14.0 [3.3–25.0]	16.0 [8.0–40.0]	7.0 [1.0–20.0]	0.047	0.076	0.424	0.167
<2 months	58 (16.0)	2 (5.7)	3 (33.3)
2–5 months	56 (15.5)	5 (14.3)	2 (11.1)
6–11 months	46 (12.7)	5 (14.3)	3 (22.2)
12–23 months	105 (29.0)	9 (25.7)	2 (22.2)
>24 months	98 (27.1)	14 (40.0)	1 (11.1)
Sex (male)	188 (51.9)	25 (71.4)	6 (66.7)	0.067
Period from onset to hospitalization (day)	4 [2–5]	2 [1–4.5]	3 [2–3]	0.003	0.004	0.540	1.0
Hospitalization period (day)	5 [4–6]	4 [3–5]	5 [4–5]	0.007	0.008	0.897	1.0
Fever	308 (85.1)	32 (91.4)	8 (88.9)	0.670
Rhinorrhea	280 (77.3)	18 (51.4)	8 (88.9)	0.002
Cough	344 (95.0)	32 (91.4)	9 (100)	0.510
Wheezing	95 (26.2)	11 (31.4)	1 (11.1)	0.462
WBC (/μL)	9600 [7200–12850]	11300 [7300–15300]	8900 [7100–10300]	0.207
CRP (mg/dL)	1.0 [0.2–2.7]	1.2 [0.6–2.8]	0.2 [0.1–0.8]	0.138
Admission of PICU	2 (0.6)	0 (0.0)	0 (0.0)	0.885
Diagnosis
Tympanitis	2 (0.6)	2 (5.7)	0 (0.0)	0.012
URI	14 (3.9)	13 (37.1)	0 (0.0)	<0.001
Croup	1 (0.3)	6 (17.1)	0 (0.0)	<0.001
LRI	343 (94.8)	19 (54.3)	9 (100)	<0.001

P^A: Kruskal–Wallis test or Chi-squared test, P^B, P^C, P^D: Dunn's multiple comparison tests.

P^B, RSV vs. HCoV; P^C, RSV vs. RSV + HCoV P^D, HCoV vs. RSV + HCoV.

Data are shown as median (IQR) or number (%).

IQR, interquartile range; WBC, white blood cell; CRP, C-reactive protein; PICU, pediatric intensive care unit; URI, upper respiratory infection; and LRI, lower respiratory infection.