FIGURE 4.

RBD‐OMV vaccination prevented loss of body mass after challenge with intranasal SARS‐CoV‐2, but did not affect body temperature or burrowing behaviour. (A) Syrian golden hamsters (four males and four females per treatment group) were vaccinated on days 0, 14, and 28 with RBD‐OMVs, control OMVs, or mock solution. Hamsters were challenged with 10⁷ infectious units of SARS‐CoV‐2 on day 44. (B–C) Body temperature was monitored via a subdermal chip weekly before and daily after virus challenge. (D–E) Body mass was monitored weekly before and daily after virus challenge (F–G) Mass on days 1–4 post‐challenge was measured relative to body mass on day 42. For each day post‐challenge, differences in mass loss between groups were tested by one‐way ANOVA with Tukey's post‐hoc test, n = 4, * P < 0.05