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. 2022 Mar 1;13:813979. doi: 10.3389/fimmu.2022.813979

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Copyright © 2022 Chen, Zhu, Wang, Dong, Yu, Su, Huang, Huo and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A20 negatively regulated the M1 polarization of BV2 microglia. (A) The percentage of CD16/32⁺ M1 microglia was higher in the Lv-A20 group than in the Lv-NC group. The percentage of CD206⁺ M2 microglia was lower in the Lv-A20 group than in the Lv-NC group. (B) The IL-1β, IL-6 and TNF-α expression at mRNA levels were higher in the Lv-A20 group than the Lv-NC group, and the IL-4, IL-10 and TGF-β expression at mRNA levels were lower in the Lv-A20 group than the Lv-NC group. (C) The IL-1β, IL-6 and TNF-α secretion levels were higher in the Lv-A20 group than the Lv-NC group, and the IL-4, IL-10 and TGF-β secretion levels were lower in the Lv-A20 group than the Lv-NC group. (D) The percentage of CD16/32⁺ M1 microglia was lower in the OE-A20 group than in the OE-NC group. The percentage of CD206⁺ M2 microglia was higher in the OE-A20 group than in the OE-NC group. (E) The IL-1β, IL-6 and TNF-α expression at mRNA levels were lower in the OE-A20 group than the OE-NC group, and the IL-4, IL-10 and TGF-β expression at mRNA levels were higher in the OE-A20 group than the OE-NC group. (F) The IL-1β, IL-6 and TNF-α secretion levels were lower in the OE-A20 group than the OE-NC group, and the IL-4, IL-10 and TGF-β secretion levels were higher in the OE-A20 group than the OE-NC group. Values are presented as the mean ± SD. *** indicates P < 0.001.