Figure 2.

Role of the neutrophils and macrophages in wound inflammation. (A) Neutrophils produce extracellular trapping nets of neutrophils, trigger phagocytosis, produce oxidative bursts and degranulation to remove bacteria and necrotic tissue. It,s cleared by burial, reverse metastasis of neutrophils and secondary necrosis of neutrophils; (B) Macrophages removal cell fragments, pathogens and apoptotic cells, and produce a large number of pro-inflammatory cytokines to recruit immune cells. Polarization to M2 type under the influence of TH2 cytokines, apoptotic cells, nucleotides and temporary extracellular bases.