Figure 4.

The role of keratinocytes, fibroblasts and vascular endothelium in wound inflammation. (A) Toll-like receptors activate cells to secrete cytokines, chemokines recruit immune cells, and synthesize antimicrobial peptides to kill pathogens; (B) Toll-like receptors activate cells to secrete cytokines, chemokines and colony-stimulating factors to recruit immune cells, while synthesizing antimicrobial peptides and defensins to kill pathogens, but also participate in new angiogenesis, conducive to immune cells clear and moist; (C) Circulating immune cells infiltrate into the injured tissue through capture, slow rolling, regulation of adhesion strength, crawling in the lumen, and eventually cross-cell or paracellular migration.