Table 1.
Logistic regression and Hardy-Weinberg analyses of HLA-G 14-bp Insertion/Deletion polymorphism in COVID-19 cases compared to controls.
| Model† | Allele/genotype | Cases (N = 209) |
Controls (N = 198) |
OR | 95% CI | p-value (pc) | ||
|---|---|---|---|---|---|---|---|---|
| N | % | N | % | |||||
| Allele | Ins | 181 | 43.3 | 220 | 55.6 | Reference | ||
| Del | 237 | 56.7 | 176 | 44.4 | 1.89 | 1.44–2.48 | <0.001 (0.001) | |
| Recessive | Ins/Ins + Ins/Del | 143 | 68.4 | 162 | 81.8 | Reference | ||
| Del/Del | 66 | 31.6 | 36 | 18.2 | 1.74 | 1.03–2.93 | 0.039 (0.234) | |
| Dominant | Ins/Ins | 38 | 18.2 | 58 | 29.3 | Reference | ||
| Ins/Del + Del/Del | 171 | 81.8 | 140 | 70.7 | 1.82 | 1.08–3.09 | 0.026 (0.156) | |
| Overdominant | Ins/Ins + Del/Del | 104 | 49.8 | 94 | 47.5 | Reference | ||
| Ins/Del | 105 | 50.2 | 104 | 52.5 | 1.03 | 0.66–1.61 | 0.889 (1.0) | |
| Codominant | Ins/Ins | 38 | 18.2 | 58 | 29.3 | Reference | ||
| Ins/Del | 105 | 50.2 | 104 | 52.5 | 1.60 | 0.92–2.79 | 0.097 (0.582) | |
| Del/Del | 66 | 31.6 | 36 | 18.2 | 2.39 | 1.25–4.58 | 0.008 (0.048) | |
| HWE-p-value | 0.738 | 0.371 | ||||||
†: The analysis was adjusted for age and gender; HWE: Hardy-Weinberg equilibrium; Ins: Insertion; Del: Deletion; OR: Odds ratio; CI: Confidence interval; p: Two-tailed Fisher exact probability; pc: Bonferroni correction probability. Significant p-value is indicated in bold.