Table 3.
German Oncology Center (GOC) dosimetric constraints for HDR liver BT.
| Target/OARs | Constraints used in clinical studies | GOC Constraints | GOC Special considerations |
|---|---|---|---|
| PTV (Target) | D100% = PD (11, 25, 30, 41) | V100% > 95% | PD: 25Gy |
| Healthy liver tissue (Liver-GTVs) | V5Gy < 2/3 liver volume (11, 25, 30, 41, 42) | V10Gy < 2/3 liver volume and 700cc | For Re-irradiation*: V40Gy (ΣEQD3Gy2) < 2/3 liver volume and 700cc |
| V10Gy < 2/3 liver volume (43) | |||
| Esophagus/Stomach/Duodenum/Jejunum/Ileum | D1cc < 15Gy (11, 27, 30, 44, 45) | D1cc < 15Gy | For Re-irradiation*: D1cc < 85Gy( Σ EQD3Gy2) |
| D1cc < 12Gy (46) | |||
| Dmax < 15Gy (47) | |||
| Dmax < 14Gy (42) | |||
| Colon | D1cc < 15Gy (11, 30) | D1cc < 15Gy | |
| Dmax < 18Gy (42) | |||
| Spinal Cord | D1cc < 8Gy (11, 30) | D1cc < 14Gy | For Re-irradiation*: D1cc < 75Gy( Σ EQD3Gy2) |
| Dmax < 15Gy (47) | |||
| Kidneys (for GOC: individual and combined) | V7Gy < 2/3 kidney volume (43) | D1cc < 18Gy D200cc < 10Gy Dmean < 6Gy |
For Re-irradiation*: D1cc < 90Gy(ΣEQD3Gy2) |
| D200cc < 40Gy(ΣEQD3Gy2) | |||
| Dmean < 16Gy(ΣEQD3Gy2) | |||
| Thoracic Wall | No constraint | D1cc < 23Gy | For Re-irradiation*: D1cc < 110Gy(ΣEQD3Gy2) |
| Great Vessels | No constraint | D1cc < 27Gy | For Re-irradiation*: D1cc < 240Gy(ΣEQD3Gy2) |
| Gallbladder | Dmax < 20Gy (42) | No constraint | Mandatory reporting of D1cc and Dmean |