TABLE 5.
CD4+/CD8+ T-lymphocyte ratio in peripheral blood of infant rhesus macaques following inoculation with SIVmac055 or SIVmac385
| Animal group | Animal no. | SIVa | PMPAb | CD4+/CD8+ T-cell ratio at the following times (wk) after virus inoculationc:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 6–8 | 10 | 12–15 | 18–21 | 30 | 39 | ||||
| A | 29668 | 055 | − | 4.85 | 2.74 | 0.65 | 1.10 | 1.08 | 0.52 | 0.75 | 0.87d | |||
| 29669 | 055 | − | 3.63 | 3.18 | 1.13 | 1.27 | 0.88 | 0.82d | ||||||
| 29670 | 055 | − | 3.28 | 3.69 | 1.21 | 1.41 | 1.20 | 1.64d | ||||||
| B | 29674 | 385 | − | 3.05 | 4.23 | 1.48 | 1.74 | 1.82 | 1.28 | 1.36 | 0.54d | |||
| 29675 | 385 | − | 5.42 | 7.89 | 1.57 | 1.81 | 1.21 | 1.65 | 1.58d | |||||
| 29729 | 385 | − | 4 | 2.3 | 1.33 | 1.11 | 1.00 | 0.83d | ||||||
| C | 29283 | 055 | + | 3.82 | 9.33 | 2.14 | 2.31 | 2.58 | 1.95 | 2.02 | 1.43 | 1.83 | 1.81 | 1.94d |
| 29360 | 055 | + | 3.85 | 4.06 | 1.43 | 1.28 | 1.33 | 0.96 | 0.88 | 0.65 | 0.44d | |||
| 29419 | 055 | + | 5.69 | 9.67 | 3.59 | 3.41 | 2.45 | 2.55 | NAe | 1.47 | 1.63d | |||
| D | 29276 | 385 | + | 4.35 | 4.17 | 1.82 | 1.71 | 1.88 | 1.41 | 1.45 | 1.29 | 1.37 | 0.98 | 0.87 |
| 29278 | 385 | + | 5.53 | 8.32 | 2.04 | 2.49 | 2.00 | 2.09 | 2.16 | 1.54 | 1.75 | 1.87 | 1.13 | |
| 29279 | 385 | + | 3.73 | 4.04 | 1.64 | 1.61 | 1.76 | 1.29 | 1.68 | 1.00 | 1.24 | 1.22 | 1.23 | |
Animals were inoculated at birth with SIVmac055 (055) or SIVmac385 (385).
Groups C and D were started on PMPA treatment 3 weeks after virus inoculation.
Ratios of <1 are indicated in boldface.
Time of death.
NA, not available.