Table 3.

Independent factors of clinicopathological, surgical, and pathological features on shorter overall survival

	Univariate analysis			Multivariate analysis
	HR	p	95% CI	HR	p	95% CI
Age (> 66 vs ≤ 66)	0.962	0.889	0.561–1.650
Transthoracic approach (thoracotomy vs MIE)	1.041	0.883	0.607–1.785
Reconstruction (colon conduit vs gastric conduit)	2.093	0.090	0.891–4.915
All infectious complications (+ vs −)	1.181	0.548	0.686–2.035
AL (+ vs −)	1.114	0.736	0.595–2.084
Pneumonia (+ vs −)	1.518	0.138	0.874–2.635
SSI (+ vs −)	1.224	0.481	0.698–2.147
Adjuvant therapy (+ vs −)	1.383	0.238	0.807–2.371
Neoadjuvant chemotherapy (+ vs −)	2.301	0.004	1.302–4.067	1.353	0.306	0.758–2.416
Pathological stage (≥ II vs < II)	14.803	< 0.001	3.601–60.857	10.947	0.001	2.590–46.268
Change of PNI level (Group L–L vs other groups)	3.022	< 0.001	1.746–5.228	2.171	0.006	1.249–3.775

HR hazard ratio, CI confidence interval, MIE minimally invasive esophagectomy, AL anastomotic leakage, SSI surgical site infection, PNI prognostic nutritional index