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. 2022 Feb 19;96(4):1109–1131. doi: 10.1007/s00204-022-03239-9

Fig. 4.

Fig. 4

Relationship between total Clint of alkylated phenanthrenes and the number of carbon atoms in the alkyl side chain in metabolism with a RLM and b HLM. The intrinsic clearance was calculated by adding up the Clint values of all metabolites for the respective model compound (Table 1)