Table 2.

Comparison between DTC patients with excellent response and not excellent response 1 year after RAIT

Variable			Univariate	Multivariate
	Excellent response n 146	Not excellent response n 128	p value	HR (95%CI)	p value
Age, mean (years)	14.8	14	0.043	1.022 (0.926–1.127)	0.663
Gender F:M	105:41 (72%:28%)	85:43 (66%:34%)	0.171
Puberty	118 (81%)	93 (72%)	0.109
Decade of diagnosis			0.425
1990–2000 + 2001–2010	79 (54%)	75 (58%)
2011–2020	67 (46%)	53 (42%)
Histotype			0.120
Papillary	80 (55%)	72 (56%)
Follicular var of papillary	30 (21%)	29 (23%)
Follicular	12 (7.4%)	6 (5%)
Aggressive variant	20 (14%)	21 (16%)
Hurtle cell	3 (2%)	0
NIFPT	1 (0.6%)	0
Capsule invasion	56 (38%)	81 (63%)	< 0.001	1.602 (0.849–3.027)	0.145
Vascular invasion	32 (22%)	57 (44%)	< 0.001	1.236 (0.620–2.464)	0.547
Thyroiditis	29 (14%)	35 (27%)	0.154
Tumor size, mean (mm)	19	25	0.007	1.157 (0.935–1.431)	0.179
Multicentricity	48 (33%)	51 (40%)	0.249
ATA class risk			< 0.001	1.390 (0.845–2.286)	0.194
Low	77 (46%)	24 (19%)
Intermediate	79 (47%)	65 (51%)
High	12 (7%)	39 (30%)
History of cancer	17 (12%)	16 (12.5%)	0.739
sTg at the time of ablation, mean (ng/ml)	19.8	126.1	< 0.001	5.02 (2.440–10.330)	< 0.001
TgAb positive at ablation	31 (21%)	42 (32%)	0.036	2.22 (1.154–3.345)	0.040
First RAI activities administrated, mean (GBq)	2.7	2.7	0.680

F female, M male, RAIT radioactive iodine therapy, NIFPT noninvasive follicular thyroid neoplasm with papillary-like nuclear features, sTg stimulated thyroglobulin, Ab antibodies