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. 2021 Oct 15;49(4):1298–1310. doi: 10.1007/s00259-021-05572-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Representative [¹⁸F]FDG PET images of metabolic bulk volume (MBV) and total metabolic tumor volume (TMTV) delineation. a Anterior maximum intensity projection image. b The VOIs of cervical (red), iliac (yellow and purple), and inguinal (green) lymph nodes were semiautomatically delineated using the 41% SUVmax threshold method. The VOI of inguinal lymph node (green) represents the MBV. c TMTV (blue) was constructed using the “save all in one” function in LIFEx