Table 2.
Diagnostic performances of hybrid nomograms, radiomic signatures and IPI score
| End points | Models | Training cohort | Validation cohort | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC (95% CI) | Sens (%) |
Spec (%) |
PPV (%) |
NPV (%) |
DeLong test P * |
HL test P |
AUC (95% CI) | Sens (%) |
Spec (%) |
PPV (%) |
NPV (%) |
DeLong test P * |
HL test P |
||
| PFS | Hybrid nomogram | ||||||||||||||
| TMTV-HNPFS | 0.828 (0.721–0.916) | 80.0 | 73.3 | 50.0 | 91.7 | < 0.001 | 0.389 | 0.781 (0.647–0.905) | 75.0 | 75.0 | 57.1 | 87.1 | 0.041 | 0.110 | |
| MBV-HNPFS | 0.835 (0.729–0.922) | 80.0 | 74.7 | 51.3 | 91.8 | < 0.001 | 0.276 | 0.787 (0.651–0.907) | 75.0 | 77.8 | 60.0 | 87.5 | 0.017 | 0.431 | |
| Radiomic signature | |||||||||||||||
| TMTV-RSPFS | 0.819 (0.724–0.909) | 84.0 | 66.7 | 45.7 | 92.6 | 0.104 | 0.231 | 0.748 (0.596–0.886) | 81.3 | 66.7 | 52.0 | 88.9 | 0.285 | 0.398 | |
| MBV-RSPFS | 0.806 (0.704–0.898) | 84.0 | 62.7 | 42.9 | 92.2 | 0.455 | 0.620 | 0.759 (0.595–0.888) | 68.8 | 80.5 | 61.1 | 85.3 | 0.209 | 0.548 | |
| IPI score | 0.701 (0.592–0.796) | 76.0 | 64.0 | 41.3 | 88.9 | NA | NA | 0.663 (0.512–0.798) | 68.8 | 63.9 | 45.8 | 82.1 | NA | NA | |
| OS | Hybrid nomogram | ||||||||||||||
| TMTV-HNOS | 0.818 (0.699–0.912) | 80.0 | 66.3 | 37.2 | 93.0 | 0.005 | 0.492 | 0.785 (0.632–0.925) | 78.6 | 71.1 | 50.0 | 90.0 | 0.038 | 0.188 | |
| MBV-HNOS | 0.831 (0.723–0.916) | 80.0 | 72.5 | 42.1 | 93.5 | < 0.001 | 0.549 | 0.792 (0.621–0.936) | 78.6 | 76.3 | 55.0 | 90.6 | 0.013 | 0.259 | |
| Radiomic signature | |||||||||||||||
| TMTV-RSOS | 0.803 (0.681–0.898) | 85.0 | 62.5 | 36.2 | 94.3 | 0.563 | 0.403 | 0.742 (0.554–0.917) | 71.4 | 73.7 | 50.0 | 87.5 | 0.268 | 0.219 | |
| MBV-RSOS | 0.815 (0.719–0.904) | 90.0 | 66.3 | 40.0 | 96.4 | 0.096 | 0.336 | 0.757 (0.586–0.906) | 78.6 | 68.4 | 47.8 | 89.7 | 0.192 | 0.567 | |
| IPI score | 0.713 (0.606–0.807) | 80.0 | 62.5 | 34.8 | 92.6 | NA | NA | 0.652 (0.483–0.795) | 64.3 | 65.8 | 40.9 | 83.3 | NA | NA | |
AUC area under the curve, CI confidence interval, Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value, HL Hosmer–Lemeshow, PFS progression-free survival, TMTV total metabolic tumor volume, HN hybrid nomogram, MBV metabolic bulk volume, RS radiomic signature, IPI International Prognostic Index, NA not applicable, OS overall survival
*P value was calculated by comparing AUC with that of the IPI score