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. 2022 Feb 5;96(4):1009–1019. doi: 10.1007/s00204-022-03231-3

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© The Author(s) 2022

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Fig. 1 — Conceptual representation of the PBPK model to study CD exposure in rats and humans. For rats, only CD is described, as there is almost none of the metabolite CD-OH. For humans, CD-OH is present as the major metabolite. The structure is the same for both species