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. 2022 Feb 5;96(4):1009–1019. doi: 10.1007/s00204-022-03231-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Profile simulation reproducing the daily exposure of 671 adult healthy males from FWI. Three groups of blood concentrations were measured: Gr. 1 (n = 166), Gr. 2 (n = 337), and Gr. 3 (n = 168). Lines represent the simulation. Dots represent the blood concentration for each group for 1000 days. The measurements at 1000 days are arbitrary and correspond to the SS in blood based on a half-life of 131 days