Table 2.
Linear model coefficients accounting for the effects of demographic factors, cortical FBP SUVR, and adjusted NAWM and WMH FBP SUVR on CSF and plasma biomarkers among A + individuals
| A + | |||
|---|---|---|---|
| CSF Aβ-42 | CSF p-tau181 | Plasma NfL | |
| Model 1 coefficients | |||
| Age | -0.02 | 0.00 | 0.46*** |
| Female sex | 0.36*** | 0.3** | 0.20* |
| MCI | 0.20 | 0.38** | 0.21 |
| AD | 0.00 | 0.57*** | 0.39* |
| Cortical SUVR | -0.23*** | 0.23*** | 0.10* |
| Adjusted NAWM SUVR | 0.52*** | -0.15** | -0.13** |
| Model 2 coefficients | |||
| Age | -0.01 | 0.03 | 0.46*** |
| Female sex | 0.37*** | 0.29** | 0.20* |
| MCI | 0.06 | 0.44** | 0.27* |
| AD | -0.24 | 0.66** | 0.49** |
| Cortical SUVR | 0.05 | 0.16*** | 0.04 |
| Adjusted WMH SUVR | 0.42*** | -0.12* | -0.07 |
Linear models including age, sex, clinical diagnosis, cortical FBP SUVR, and NAWM (Model 1) or WMH (Model 2) FBP SUVR as covariates were fitted to describe fluid biomarker levels (dependent variables). Model coefficients of continuous variables were reported as standardized βs. Categorical variable coefficients describe the change in z-score units of fluid biomarkers (references were CN and male sex)
*p < 0.05, **p < 0.01, ***p < 0.001