Table 3.

Linear mixed model time-interaction coefficients accounting for the effects of demographics, WMH volume, cortical FBP SUVR, and adjusted NAWM FBP SUVR on longitudinal change in ADAS-Cog 13

	A- CN	A + CN	A + MCI
Coefficients
Age × time	0.02	0.00	− 0.03*
Female sex × time	0.07**	0.03	0.02
Education × time	0.02	0.02	0.04*
WMH × time	0.01	0.00	0.01
Cortical SUVR × time	0.02	0.06*	0.09***
Adjusted NAWM SUVR × time	0.00	− 0.04*	− 0.07***

Linear mixed models included fixed effects of age, sex, education years, WMH volume, cortical FBP SUVR, and adjusted NAWM FBP SUVR, as well as their interactions with time. Coefficients represent the annual change in ADAS-Cog 13 (in baseline standard deviation units) with 1 standard deviation change of the baseline covariate.

^*p < 0.05, **p < 0.01, ***p < 0.001