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. 2021 Dec 7;49(4):1345–1359. doi: 10.1007/s00259-021-05641-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Radionuclide imaging of apoptosis can be served as diagnostic markers, early-response indicators, and prognostic predictors in tumor. A A spinocellular carcinoma of the tongue basis in CT and corresponding ^99mTc-Annexin V SPECT, indicated by small arrows. B A primary tumor located in the lip is showed in ^99mTc-Annexin V SPECT (left, indicated by small arrows) along with a Kaplan–Meier plot of overall survival (right). C ^99mTc-Annexin V SPECT early after treatment shows a significant increase in tumor uptake (black arrows) with a complete response on CT scan 1 month later (white arrows). D ^99mTc-Annexin V SPECT early after treatment shows a decrease in tumor uptake (black arrows) with a stable disease on CT scan 1 month later (white arrows). (The researches were originally published in Nucl Med Commun. 2004 Mar;25(3):259–63 [39], Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):47–52 [56], Nucl Med Commun. 2008 Jan;29(1):39–44 [48], respectively. Reprint permission was obtained)