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. 2022 Jan 1;25(2):313–326. doi: 10.1007/s00737-021-01185-6

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© Janssen Research & Development, LLC 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Response and remission rates by sex and treatment group in the TRANSFORM trials. CI = confidence interval. Notes: Response defined as ≥ 50% decrease from baseline Montgomery-Asberg Depression Rating Scale (MADRS) total score. Remission defined as MADRS total score ≤ 12. Odds ratio = odds of achieving response on esketamine + antidepressant divided by the odds of achieving response on antidepressant + placebo