Fig. 4. RUBCN-deficient female mice display splenic atrophy but no signs of autoimmunity at 50 weeks of age.

A Male and female RUBCN-deficient mice fail to gain weight over their first 50 weeks of life compared to wild-type littermates (also see Fig. S6 for details). B In contrast to male mice, female mice show splenic atrophy at an age of 50 weeks as estimated by splenic weight. C Male and female wild-type mice and RUBCN-deficient littermates produce indistinguishable levels of autoantibodies against double-stranded DNA at 36 weeks and 50 weeks of age. Statistical analysis was performed one-way ANOVA analysis (*p < 0.05, **p < 0.01, ***p < 0.001).