Figure 3.

Pyroptosis is Regulated by Numerous Phosphorylation Events. The toll-like receptor 4 (TLR-4) activate Jun N terminal kinase 1(JNK1), which primes NLRP3 by direct phosphorylation at S198. The PAK1 promote phosphorylation of pro-caspase-1. Mitosis A-Related Kinase 7 (NEK7) and Bruton’s tyrosine kinase (BTK) promote NLRP3 activation through direct interaction. They are regulated activation of the NLRP3 inflammasome, cleavage of GSDMD protein punch holes on the cell membrane and promoted the occurrence of pyroptosis.