Table 3.
Key kinases and phosphatases that regulate inflammatory cell death.
| Types of cell death | Targets | Enzymes | Function and effect |
|---|---|---|---|
| Necroptosis | RIPK1 | IKKα/β | Phosphorylation (–) |
| TBK1 | Phosphorylation (–) | ||
| IKKϵ | Phosphorylation (–) | ||
| MK2 | Phosphorylation (–) | ||
| TAK1 | Phosphorylation (–) | ||
| MLKL | RIPK3 | Phosphorylation (+) | |
| TAM | Phosphorylation (+) | ||
| RIPK3 | Ppm1b | Dephosphorylation (–) | |
| Apoptosis | P53 | TP53INP1 | Phosphorylation (+) |
| Pyroptosis | GSDMA | PLK1 | Phosphorylation (–) |
| NLRP3 | TAK1 | Phosphorylation (–) | |
| PTEN | Dephosphorylation (+) | ||
| Ferroptosis | BECN1 | AMPK | Phosphorylation (+) |
| HSPB1 | PKC | Phosphorylation (–) |
(–): Inhibit, (+): Promote.