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. 2022 Mar 1;10:837619. doi: 10.3389/fbioe.2022.837619

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Copyright © 2022 Andress, Irwin, Puranam, Hoffman and McNulty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-1 treatment induces significant changes in gene expression. Volcano plots showing genes significantly up and downregulated by IL-1α (0.1 ng/ml) treatment in (A) inner zone cells in monolayer (B) inner zone tissue explants (C) outer zone cells in monolayer, and (D) outer zone tissue explants. Each data point is an individual gene; y-axis capped at 300 (adjusted p-value < 10^–300). Color denotes if the gene was significantly upregulated (blue), downregulated (green), or not significant (black). Dashed lines indicate cutoffs for significant genes (FDR adjusted p-value < 0.05 and a base-2 log fold-change > |1|).