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. 2022 Mar 1;10:837619. doi: 10.3389/fbioe.2022.837619

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Copyright © 2022 Andress, Irwin, Puranam, Hoffman and McNulty.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The majority of pathways upregulated by IL-1α are downregulated by dynamic cell stretch in the presence of IL-1α. Pathways significantly differentially regulated with IL-1α stimulation are compared to significantly differentially regulated pathways with dynamic loading in the presence of IL-1α for inner (A) and outer (B) zones. Cell stretch and tissue compression normalized enrichment scores (NES) are shown in each column. A NES > 0 identifies upregulated (blue) pathways and a NES < 0 identifies downregulated (green) pathways. White boxes denote that the geneset did not meet the cutoff for significance (FDR < 0.25).